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Abstract Each year, hundreds of international researchers enter Greenland to conduct scientific fieldwork. Historically, they have had little interaction with local communities and scientists at Greenland research institutes. Recognising that collaboration between Greenland and the United States can yield better research, consider more diverse perspectives, articulate the benefits of research to Greenland society, and train the next generation in a collaborative framework, representatives from both countries have been engaged in a series of events to cultivate bilateral relationships. Here, we describe the process of these events (workshops, conference sessions, and public dialogues), the findings, and the outcomes that have followed. Prior to this focused engagement, United States and Greenland scientists typically pursued their research independently. Since the engagement, more researchers from both countries have successfully partnered to obtain funding for collaborative research. Furthermore, development of a bilateral collaboration network is underway. The focused approach on bilateral engagement also proved essential for maintaining research and other activities during the global pandemic. When United States researchers were prevented from entering Greenland, their Greenland partners were able to continue the fieldwork, ensuring that progress was not lost. Future international projects can build on these successes to expand collaborative and interdisciplinary research in Greenland.